#Caganic Nano

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GlyNAC looked like one of the most promising anti-aging supplements—but it probably isn’t for most people. 🧪 GlyNAC combines glycine and N-acetylcysteine to provide two of the three building blocks needed to make glutathione, one of the body’s most important antioxidants. In animals, GlyNAC increased glutathione and shifted survival so more animals lived longer. In older adults, GlyNAC increased muscle glutathione after 2 weeks and again after 16 weeks. Markers of oxidative stress dropped, inflammatory markers improved, and physical function improved too, including gait speed, grip strength, and chair-rise performance. But the people showing these benefits were mostly older adults, typically in their 70s, and people with chronic metabolic disease such as type 2 diabetes. In younger, healthy individuals, glutathione levels barely changed over the same time frame. Their baseline antioxidant system was already functioning well, so GlyNAC did not create the same rebound. The dose used in human studies was also high: around 100 mg/kg/day of glycine and 100 mg/kg/day of NAC. Lower-dose use is still more speculative. Another major limitation: all human randomized trials so far come from one research group, so independent replication is still needed. Main Points Summary GlyNAC raises glutathione, lowers oxidative and inflammatory stress, and improves physical function in older adults. The most likely beneficiaries are older adults and people with chronic metabolic disease. Younger, healthy people are much less likely to benefit. Human study doses are high, and all current randomized human evidence comes from one lab. References [117] Kumar P, Osahon OW, Sekhar RV. Nutrients. 2022. doi:10.3390/nu14051114 [118] Kumar P, Liu C, Hsu JW, et al. Clin Transl Med. 2021. doi:10.1002/ctm2.372 [119] Kumar P, Liu C, Suliburk J, et al. J Gerontol A Biol Sci Med Sci. 2023. doi:10.1093/gerona/glac135 [638] Sekhar RV. Antioxidants (Basel). 2022. doi:10.3390/antiox11010154

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En los estudios clínicos de GlyNAC (glicina + NAC) para aumentar los niveles de glutatión, se utilizó la siguiente dosis: Dosis utilizada en el estudio en adultos mayores (Sekhar / Kumar) • Glicina: 100 mg por kilo de peso corporal al día • NAC: 100 mg por kilo de peso corporal al día Se usaron en proporción 1:1. Ejemplos prácticos Para entenderlo fácil: Si pesas 50 kg → 5 gramos de glicina + 5 gramos de NAC al día 60 kg → 6 g de glicina + 6 g de NAC 70 kg → 7 g + 7 g 80 kg → 8 g + 8 g Importante: Estas fueron dosis terapéuticas utilizadas en un estudio clínico para restaurar niveles de glutatión en adultos mayores. No necesariamente son dosis de mantenimiento para todas las personas. #antienvejecimiento #glicina #nac #glutation

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