#Comt Gene

You’re not crazy, you just have a COMT gene mutation. The COMT gene (catechol-O-methyltransferase) provides instructions for making an enzyme that breaks down certain chemicals in the brain — especially the neurotransmitters dopamine, epinephrine (adrenaline), and norepinephrine (noradrenaline). These neurotransmitters are important for mood, stress response, focus, and emotional regulation. There’s a common variation (or “polymorphism”) in the COMT gene called Val158Met. Everyone has two copies of this gene, and there are three possible combinations: • Val/Val – fast COMT enzyme • Val/Met – medium-speed enzyme • Met/Met – slow COMT enzyme This “speed” refers to how quickly the COMT enzyme clears dopamine and other stress-related neurotransmitters from the brain. Slow COMT (Met/Met) = Breaks down dopamine slowly = Higher dopamine levels, especially in the prefrontal cortex (PFC) = Can lead to increased sensitivity to stress, anxiety, rumination, or even overthinking Fast COMT (Val/Val) = Breaks down dopamine quickly = Lower dopamine levels in the PFC = Can result in focus issues, impulsivity, or difficulty with executive function, but potentially lower anxiety Knowing if you have a COMT gene mutation can help because it gives insight into how your brain handles stress, emotions, focus, and certain medications/supplements. Follow for more #nervoussystemhealing #nervoussystemregulation #nervoussystem #comt #comtgene #genetics #mentalhealth #anxiety #panicattack #rootcause #magnesium

Ever wonder why some days you’re sharp, motivated, and in a great mood and other days you’re irritable, foggy, and can’t focus to save your life?   Meet your COMT gene.   COMT has A LOT of jobs in your body. And depending on how it’s functioning, you’ll experience very different symptoms.   When COMT is working too slowly: • Irritability • PMS • Insomnia • Headaches   When COMT is working too fast: • Difficulty concentrating • Poor motivation • That “lazy” feeling you can’t shake   When COMT is working well: • Motivated • Stable, good mood • Able to learn and focus with ease   These aren’t character flaws or things you just have to live with. This is your biochemistry—and you can influence it. I wrote an entire chapter on the COMT gene in my book, Dirty Genes, because understanding this one gene can be a game-changer for so many people.   The book is under $10 on Amazon right now.   Learn what’s actually driving your symptoms and what to do about it.   💬 Comment “DNA” to watch the full video on the truth about your genes. I walk through each of the Super Seven genes—like MTHFR, COMT, PEMT, and more—what they actually do, and what really influences how they’re expressed. You’ll also get access to our Super Seven Guide and the Dirty Genes book.    #comt #comtgene #stress #methylation #dopamine

⚖️ Gary Brecka: COMT Gene & Weight Loss Struggles 🧬 1️⃣ Gary explains that a COMT gene mutation can slow how your body processes dopamine and stress hormones — which directly affects metabolism and fat loss. 🔥 2️⃣ For many, this means harder time losing weight, constant cravings, and storing more body fat despite diet and exercise. 🍽️➡️🥵 3️⃣ The solution? A gene test to identify COMT mutations and then supplement with the right raw materials to bring your body back into balance. ⚡️ 💬 Comment “GENE” to unlock the test that reveals why your body may be holding onto fat. #GaryBrecka #WeightLossStruggles #GeneTest #COMT #MetabolismFix #FatLossJourney #RootCauseHealing #NutrientDeficiency #BiohackingHealth #MTHFR #GENE

🧬The COMT gene is involved in detoxifying catechols (from estrogen, dopamine, adrenaline). • COMT mutations can increase risk of estrogen-driven cancers → (Lavigne et al., Cancer Epidemiology, 2007) • Impaired COMT function raises oxidative stress + neuroinflammation → (Tunbridge et al., Molecular Psychiatry, 2006) • COMT polymorphisms also linked to anxiety, mood swings, and poor stress recovery This is why genetic testing matters. And why your terrain-based response is everything. Comment “PROTOCOL” to get my recovery guide Comment “EMAIL” for my COMT support strategy Comment “CONSULT” to work with me personally 👉Check your messages!! ⚠️ DISCLAIMER: For educational purposes only. Always work with a functional provider for gene-based support. #COMTmutation #HealingTerrain #CancerAndGenes #EstrogenDetox #DrPeteSulack #ResilienceProtocol #CommentProtocol #CommentEmail #CommentConsult #BrainCancerSurvivor #FaithOverFear

There’s also something called the COMT gene mutation, and what the COMT gene is responsible for is kind of holding those dopamine levels at a good amount in your brain. And so someone might have a slow COMT, and in that case, the dopamine levels can actually raise too much in the brain and cause irritability and anxiety, or someone might have a really fast COMT gene mutation, and that means that somebody’s just cycling through that dopamine really quickly, and they’re gonna feel worse mood-wise. So it’s kind of connected to the MTHFR, where you have the MTHFR pathway connected to the COMT pathway. So both of those things are really crucial to evaluate, especially if you’re considering supplementing with either amino acids or maybe some magnesium. It can be super helpful to really maximize that whole person health. #COMT #dopamine #MTHFR #aminoacids #magnesium #personhealth

If you have ADHD and hormonal issues… you need to know about this gene. This is part 4 of our Genetics Mini-Series and today we’re talking about COMT — one of the most important genes we see in ADHD, mental health and hormones. At Luna Wellness Collective, Mel and I use genetics to help ADHDers understand why their moods, cycles and focus feel so up-and-down — and COMT is a big piece of that puzzle. So what does COMT do? COMT helps your body break down dopamine, stress hormones and even oestrogen. And depending on your variation, it can run slow or fast: Slow COMT: dopamine hangs around too long → racing thoughts, anxiety, tension, jaw clenching, feeling “wired but tired,” heavy or painful periods. Fast COMT: you burn through dopamine quickly → low motivation, low mood, feeling flat, difficulty focusing, stress sensitivity. Nutritional support for COMT: Magnesium is the big one. But you also need good levels of B12, B6 and folate (from whole foods or practitioner-guided supplementation) to help this pathway function properly. If you feel like your dopamine, mood and hormones never quite meet in the middle… COMT might be part of your story. 👉 Watch the full mini-series to learn the other key genes we look at in clinic. 👉 Comment GENETICS if you want the guide. #ADHDNaturopath #ADHDWomen #ADHDAndHormones #ADHDAustralia #NeurodivergentWomen #COMTGene #GeneticsAndHealth #ADHDMentalHealth #ADHDSupport #ADHDCommunity #HormoneHealthForWomen #WomensHormones #PerimenopauseSupport #PMDDHelp #FunctionalMedicine #NaturopathyAustralia #ADHDClinic #ADHDLife #ADHDEducation #LunaWellnessCollective

These are the people who should never be taking DIM for estrogen detox…👇 Here’s why: DIM pushes more estrogen down the 2-OH pathway. If your COMT gene is slow, you can’t clear that pathway efficiently. Instead of helping, DIM can leave you with a traffic jam of estrogen metabolites → worsening estrogen dominance, PMS, anxiety, headaches, or histamine flares. What to do instead? Support the other clearance pathways: ✨ Glucuronidation ✨ Sulfation ✨ Methylation ✨ Bile support 🚫 COMT inhibitors to avoid if your COMT is already slow: – DIM – Quercetin – Luteolin – Green tea extract (EGCG in high doses) 👉 Drop “COMT” in the comments and I’ll send you my list of slow COMT-friendly estrogen detox + histamine supports. Ready to uncover the root cause of your histamine and estrogen symptoms? Comment LABS To learn about the key labs needed so you can stop suffering and start feeling like you again. #histamineintolerance #lowhistaminediet #estrogendominance #methylation #estrogendetox

With guidance from my naturopath, I did private genetic testing and although I don’t carry any of the common cancer genes, I do have about half a dozen genetic variants that created ideal conditions for cancer to develop. 🧬 I have a COMT genetic variant that would have prevented my body from methylating / metabolizing estrogen well (and estrogen is a carcinogen) 🧬 I have two MTHFR variants that would have suppressed my detox pathways, increased inflammation in my body & weakened my immune system 🧬 I have a gene that predisposes me to low vitamin D, and one that leads to low B12 🧬 and the list went on.. All of these things are common precursors to cancer: the low vitamin D, b12, high inflammation, etc. I honestly never believed it when I was told that this was just “bad luck”. I knew there had to be a root cause - I just had to look for it. So, now I know how I got here, and my next step is to work with my naturopath & functional medicine doctor to ensure I’m properly detoxing, methylating, metabolizing, and getting the right nutrients for my body. With their help, I’m diving into the world of epigenetics - learning to play above my genes to repair and heal my body. Your genetics provide a blueprint, but your daily choices create an epigenetic overlay that can significantly influence how these genes actually function in your body. That’s why two people with identical genes might experience very different symptoms based on their lifestyle and environment. So here we are… tapping into the world of epigenetics and over-riding my genes to connect with a future version of me that doesn’t have cancer. I can’t wait to prove to you that I can do this. Someone, please start studying me. 😂 #breastcancer #healingjourney #healing #stageivbreastcancer #breastcancerawareness #metastaticbreastcancer #cancerthriver #cancerwarrior #cancer #stageivcancer #epigenetics #genetictesting #mthfr #comtgene #mthfrgenemutation #quantumhealing #quantumphysics #quantumfield

Are you a worrier or a warrior? 😖 Did you know that the COMT gene plays a crucial role in breaking down chemical messengers in our body? 🧬 If you have the ‘warrior’ variant for this gene, you may break down stress-related chemical messengers more quickly, which may help you improve your performance under stress. On the other hand, people with the ‘worrier’ variant may have lower COMT enzyme activity. They break down stress-related chemical messengers more slowly in the brain. And for this reason, they may be more vulnerable to stress. ⚠️ Having the warrior gene may help you perform better under stress, but did you know it can also impact your cognitive performance in relaxed conditions? High COMT activity breaks down neurotransmitters faster, which can affect tasks like working memory. Worriers, however, may become more emotionally resilient with age and excel in cognitive performance under relaxed conditions. 🎧 Listen to our SNPit episode #2 to learn all about this gene! 👉 Curious about which variant you carry? Get your DNA tested with @selfdecode! . . . . #thejoecohenshow #podcast #comt #worrier #warrior #optimalhealth #brainhealth #brainhealthtipss #neuroplasticity #cognition #cognitive #cognitivefunction #cognitivehealth

It’s not in your head. It’s called the COMT gene 🧬 This gene (which produces the COMT enzyme), is responsible for detoxing the estrogen in our body. Those with a slow COMT gene are more prone to things like anxiety, heavy periods, having bursts of energy and then crashing, insomnia, and being “on-edge” all the time. For a slow COMT gene, it’s crucial to keep your stress hormones low and environment (including your diet), as “clean” as possible. 🔑 For an list of ways to lower your cortisol during perimenopause, comment “CORTISOL” 👇🏻

Explainer on GMOs. 3 part series (or more) please watch the whole series if you want to discuss #gmo #geneticengineering

✨The COMT gene is really important for getting things out of the liver after your liver has processed it! 🩸If you have low COMT function this can lead to a build up of estrogen, which can throw our hormones off! It also can lead to a build up of things like dopamine and adrenaline which can lead you to be more on edge, have more anxiety and feel restless. 🌿Comment COMT to see some of my favorite support supplements! #methylationsupport #comtgene #anxietyrelieftips #estrogendominance #healthandwellnesstips